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KMID : 1007420090070020126
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Mood and Emotion
2009 Volume.7 No. 2 p.126 ~ p.130
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Relationship of Tryptophan Hydroxylase and Serotonin 2A Receptor Gene Polymorphisms with Affective Temperaments
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Jhng Kyung-Un
Kang Jee-In
Namkoong Kee
Kim Se-Joo
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Abstract
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Objectives：Increasing data support a continuum between mood disorders and affective temperaments which are suggested to be heritable. The aim of this study is to investigate the possible relationship between affective tem- peraments and polymorphisms of two candidate serotonergic genes, tryptophan hydroxylase 1 (TPH1) and sero- tonin receptor 2A (5-HT2A) genes.
Methods：334 healthy college students were recruited. DNA was isolated from whole blood cells, and TPH1 and 5-HT2A polymorphisms were genotyped. Participants completed the 110- item version of the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego autoquestionnaire (TEMPS- A) measuring five affective temperamental traits.
Results：No significant association was shown between affec- tive temperaments and TPH1 and 5-HT2A gene polymorphisms.
Conclusion：In Korean population, there was no significant association between affective temperaments and TPH1 and 5-HT2A gene polymorphisms. Further stu- dies will be needed in different ethnic groups to understand the genetic basis of affective temperaments.
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KEYWORD
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Tryptophan hydroxylase·Serotonin 2A receptor, Polymorphism, Affective temperament, TEMPS- A
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